Hema Pharmaceuticals is counted as a major manufacturer and supplier of Esomeprazole Sodium in the industry. It is the sodium salt of the S-isomer of omeprazole, having gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfonamide. The active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase. It thereby inhibits its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.