Tenofovir Disoproxil Fumarate

Tenofovir Disoproxil Fumarate is prescribed for treatment of chronic hepatitis B & HIV/AIDS. It is a nucleotide analog reverse-transcriptase inhibitor that has ability to inhibit viral reverse transcriptase. This compound show elimination half life of about 17 hours and gets excreted via kidney. It quickly gets absorbed from gut and shows bioavailability of only about 25%. Tenofovir also shows inhibition of DNA polymerases and prevents formation of 5' to 3' phosphodiester linkage required for DNA chain elongation. Tenofovir Disoproxil Fumarate is also known to have ability to inhibit cytochrome P450 1A2 and also to prevent viral replication.